Author : Şerife akkÜÇÜk, Özlem makbule kaya, mehmet yaman
Keyword : Leishmaniasis, animal models, leishmania species
Subject : Microbiology
Article Type : Review article
Article File : Full Text PDF
Abstract : Leishmaniasis is a zoonotic disease that has worldwide importance and is hard to control and treat. Researchers have not yet developed a protective vaccine for humans in the light of current studies. Various experimental animal models are being used since; i) Leishmania has different species and vectors, ii) there are still many clinical, pathological, and immunological issues that have to be investigated, iii) new non-toxic medical recipes to have maximum yield in a short time have to be investigated, iv) protective vaccination have to be developed. Mouse, hamster, dog, rodent, and non-human primates are among these animal models. None of them has the same clinical features, pathogenesis, and immunology with the disease in humans. However, rodents, dogs, and monkeys, which are the last host of the parasite, are among the most preferred models in recent days. Considering the different clinical forms of the disease, it is best to decide which Leishmania species to work with which animal. This review is intended to guide the researchers in choosing an appropriate animal model for leishmaniasis studies.
Article by : Ebubekir Ceylan
Article add date : 2021-01-23
How to cite : Şerife akkÜÇÜk, Özlem makbule kaya, mehmet yaman. (2021-January-23). What is the best animal model for leishmaniasis studies?. retrieved from https://openacessjournal.com/abstract/588