Author : Naina mohamed pakkir maideen
Keyword : Drug interactions, acetaminophen, paracetamol, cyp2e1, cyp1a2, ugt enzymes
Subject : Pharmacology
Article Type : Review article
DOI : 10.13187/ejm.2019.1.30
Article File : Full Text PDF
Abstract : Acetaminophen (Paracetamol) is the most frequently used Over-The-Counter (OTC) antipyretic and analgesic drug, worldwide. The metabolism of Acetaminophen is mediated by phase II reactions (UDP-glucuronosyl transferases (UGT)-mediated glucuronidation and sulfation) and phase I oxidative reactions mediated by Cytochrome P450 (CYP) enzymes including CYP2E1 and CYP1A2. The drugs inducing CYP2E1 and CYP1A2 enzymes and the drugs inhibiting UDP-glucuronosyl transferases (UGTs) may increase the exposure of NAPQI resulting in elevated risk of hepatotoxicity. The risk of acetaminophen-associated hepatotoxicity might be elevated due to concomitant use of certain medications including Isoniazid, Antiepileptic drugs, Tyrosine kinase inhibitors and Alcohol. Acetaminophen may increase the international normalized ratio (INR) by potentiating the anticoagulant effect of warfarin. To prevent possible adverse drug interactions, the prescribers and pharmacists must discuss with their patients about the use of OTC Acetaminophen.
Article by : Naina Mohamed Pakkir Maideen
Article add date : 2021-12-21
How to cite : Naina mohamed pakkir maideen. (2021-December-21). Drug interactions of acetaminophen (paracetamol) involving cyp and ugt enzymes. retrieved from https://openacessjournal.com/abstract/937