Author : P vinod kumar , princy louis palatty, achuthan cr
Keyword : Inflammatory bowel diseases; crohn’s disease; ulcerative colitis
Subject : Dermatology
Article Type : Review article
DOI : 10.31531/2231-5896.1000120
Article File : Full Text PDF
Abstract : Inflammatory bowel disorder is related to situations ulcerative colitis and Crohn’sdisorder; however, its motive is unknown and the infection may be because of changing of intestine homeostasis with innate immunity performs a crucial position in spotting pathogens, hence keeping intestinal homeostasis. In 1985,Christiane Nüsslein-Volhard and Eric Wieschaus named it toll-like receptors because of the toll gene recognized in Drosophila. Toll-like receptors signaling pathways are the myeloid differentiation factor 88-dependent pathway and TIR-domain containing adapter-inducing interferon-β-dependent pathway ends in the induction or suppression of inflammatory response. With new emerging nano-inhibitors, small molecule inhibitors, oligonucleotide, lipid- analogs, microRNAs that inhibit TLR signaling, to control excessive inflammation can we expect a new ray of hope emerging in the future?
Article by : P VINOD KUMAR
Article add date : 2022-01-24
How to cite : P vinod kumar , princy louis palatty, achuthan cr. (2022-January-24). Toll like receptors signaling in inflammatory bowel disease-are they new targets of the future?. retrieved from https://openacessjournal.com/abstract/982